Stello et al. found stage 1 EC tumours with POLE mutation and tumours without microsatellite instability and with CTNNB1 wild type are associated with favourable prognosis whereas tumours with microsatellite instability and CTNNB1 exon 3 mutations are associated with intermediate prognosis based on current risk stratification system [55]. Here, CTNNB1 is linked to neoplasm.