The IFNγ secreted by CD8+ T cells downregulates the expression of SLC7A11 and SLC3A2, and therefore attenuates the uptake of cystine by tumor cells, consequently enhancing lipid peroxidation in tumor cells, ultimately increasing ferroptosis (Dolma et al., 2003; Wang et al., 2019). The gene discussed is IFNG; the disease is neoplasm.