Of interest, C1P is highly involved in processes related to stroke such as cell migration (Granado et al., 2009b; Kim et al., 2012; Arana et al., 2013; Vera et al., 2021), invasion involving MMPs (Ordoñez et al., 2016a), cell proliferation through NO (Gangoiti et al., 2008) or vascular endothelial growth factor (VEGF) (Ouro et al., 2017), cell survival (Gómez-Muñoz et al., 2010; Gomez-Larrauri et al., 2021b), metabolism (Ouro et al., 2013), and inflammation (Nakamura et al., 2006; Gomez-Muñoz et al., 2013; Baudiß et al., 2016). This evidence concerns the gene VEGFA and stroke disorder.