Taken together, the administration of P. acidilactici XZ31 suppresses gluten-induced allergy possibly via the following ways: on the one hand, P. acidilactici XZ31 attenuates gluten-specific IgE production by shifting the Th1/Th2 immune balance toward Th1 polarization; on the other hand, P. acidilactici XZ31 alleviates intestinal inflammation by promoting the differentiation of goblet cells and increasing the abundance of beneficial intestinal bacteria. This evidence concerns the gene IGHE and Allergy.