Additionally, the up-regulation of TLR3 occurs during multiple virus infections such as Muscovy Duck Reovirus (MDRV), Duck Tembusu virus (DTMUV), and Zika virus (ZIKV) (Bendelja et al., 2010; Zhang et al., 2015; Dang et al., 2016). Here, TLR3 is linked to viral infectious disease.