PPL and bacterial infectious disease: Among the most downregulated DEGs were the interleukin 12B gene (FC = 0.046), which plays a protective role during bacterial infection (Reeme et al., 2013), the osteoblast-specific factor-2, periostin (FC= 0.112), as mentioned above, osteomodulin (FC=0.05) that functions as a positive coordinator in osteogenesis (Lin et al., 2020) and periplakin (FC=0.147), which connects cytoskeletal structures to the cell adhesion complex (Hu et al., 2018).