Since a complement system is involved in the restriction of the growth of internalized bacteria by autophagy (Sorbara et al., 2018) and a detection of deregulated autophagy-related genes (ATG2, ATG5, ATG7, ATG9) in our model, further investigations are required for the understanding of the complement system and autophagy relationship in the context of osteomyelitis. This evidence concerns the gene ATG7 and osteomyelitis.