Since a complement system is involved in the restriction of the growth of internalized bacteria by autophagy (Sorbara et al., 2018) and a detection of deregulated autophagy-related genes (ATG2, ATG5, ATG7, ATG9) in our model, further investigations are required for the understanding of the complement system and autophagy relationship in the context of osteomyelitis. The gene discussed is ATG5; the disease is osteomyelitis.