E2F3 and cancer: Compared to the benign tissue, PCa tissue showed an up-regulated expression of E2F3 (benign vs cancer = 1.49 ± 0.05 vs. 1.86 ± 0.02, p < 0.01), and a higher expression of E2F3 was also related to higher Gleason scores (GS < 7: 1.62 ± 0.06, GS = 4 + 3: 1.73 ± 0.04, GS > 7: 2.04 ± 0.04).