In PCa, E2F1 is reported to be driven by POM121 (Rodriguez-Bravo et al., 2018) and cooperates with miR-20b-5p and TGFBR2 to form a regulatory loop to participate in epithelial to mesenchymal transitions in PCa (Qi et al., 2019). The gene discussed is E2F1; the disease is posterior cortical atrophy.