E2F1 expression was higher in PCa than in benign tissues (benign vs. cancer = 1.18 ± 0.05 vs. 1.64 ± 0.03, p < 0.01), and a high E2F1 expression was associated with higher Gleason scores (GS < 7: 1.44 ± 0.06, GS = 4 + 3: 1.58 ± 0.05, GS > 7: 1.91 ± 0.05). Here, E2F1 is linked to cancer.