Kang et al. (2019) reported that lncRNA RP11-732M18.3 specifically binds 14-3-3 β/α, which facilitates p21 degradation, thereby promoting GBM cell proliferation (Figure 4). It is worth mentioning that several lncRNAs, including MATN1-AS1 (Zhu et al., 2020), ROR1-AS1 (Chai et al., 2020), and LEF1-AS1 (Cheng et al., 2020b), are capable of influencing GBM uncontrolled cell proliferation through binding with other molecules, which have been summarized elsewhere (Li et al., 2018). In addition, the dysregulated lncRNAs that regulate GBM cell proliferation are listed in detail in Table 1. The gene discussed is CDKN1A; the disease is glioblastoma.