RPL36 and central nervous system cancer: Shi et al. (2020) suggested that HOTAIRM1 represses the expression of HOXA cluster genes and GBM cell proliferation through the regulation of high-order chromatin structure. Hu et al. revealed that nucleus PLAC2 interacts with STAT1 and activates RPL36 in the transcriptional level by binding RPL36 promoters, but the cytoplasmic lncRNA PLAC2 repressed STAT1 nuclear transfer, consequently reducing RP36 expression, inhibiting glioma cell growth and arresting cell cycle progression (Figure 3A) (Hu et al., 2018a).