VHL and cancer: Another study suggested that HIF-1α–induced lincRNA-p21 in the transcriptional level and highly expressed lincRNA-p21 associates with HIF-1α and VHL, thereby leading to disrupting the VHL/HIF-1α protein complex interaction and resulting in attenuating VHL-mediated HIF-1α ubiquitination and degradation, which is essential for hypoxia-mediated glycolysis and cancer progression (Yang et al., 2014).