Several lncRNAs have been discovered that affect the pathogenesis of T2D: lncRNA betaFaar regulates islet beta-cell function and survival in T2D mice; lncRNA VEAL2 targets PRKCB2 contributing to reducing hyperpermeability in a hyperglycemic animal model (Sehgal et al., 2021; Zhang et al., 2021). This evidence concerns the gene PRKCB and type 2 diabetes mellitus.