Functional disorder of ALP leads to protein aggregation, resulting in accumulation of abnormal proteins and ineffective organelles, such as Alzheimer’s disease (AD) caused by amyloid β-protein (Aβ) deposition (Reddy and Oliver, 2019) and alpha-synuclein accumulation result in Parkinson’s disease (PD) (Cerri and Blandini, 2019). The gene discussed is SNCA; the disease is Alzheimer disease.