TFEB and neoplasm: The tumor is characterized by the fusion of the non-protein-coding gene Alpha (MALAT1) located at 11q12 and the TFEB gene of 6p21, which up-regulates the expression of TFEB, leading to abnormal expression of melanocyte markers (Argani et al., 2005; Rao et al., 2012), that is just the opposite of NDs in gene regulation.