This case report concisely emphasizes the possible mechanisms triggering atrial fibrillation including acid-base imbalances/electrolyte abnormalities, endothelial damage, cytokine storm, decreased ACE-2 availability, sympathetic drive stimulation, systemic inflammation, microthrombi formation, myocardial injury, and increased adrenergic drive in patients with COVID-19 infection. The gene discussed is ACE2; the disease is atrial fibrillation.