To induce puberty in adolescent boys with CHH, various treatment protocols have been used, including hCG alone or in combination with FSH. The treatment regimen varies between 1,000-1,500 IU for hCG and 75-150 IU for FSH administered intramuscularly three times per week [72]. The hCG dose is to be titrated based on testosterone levels, whereas the FSH dose is usually adjusted based on clinical signs [72]. Here, BRD2 is linked to cartilage-hair hypoplasia.