These cascades of reactions enable the synthesis and release of numerous proinflammatory cytokines, including interferon (IFN)-α, IFN-γ, interleukin (IL)-1β, IL-6, IL-12, IL-18, IL-33, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β, and chemokines, like chemokine ligand (CCL) 2, CCL3, CCL5, CXC chemokine ligand (CXCL) 8, CXCL9, and CXCL10, in the form of "cytokine storm" further neutralizing the virus and contributing to the collateral damage of endothelial dysfunction, permeable vessels, and lipid membrane peroxidation [15,27,37]. The gene discussed is TNF; the disease is endothelial dysfunction.