Both DCLRE1B and PARN have been implicated in short telomere syndrome (STS) patients.30, 31, 32 DCLRE1B protein localizes to the telomere via interaction with the protein of another previously implicated GWAS gene, TERF2, and contributes to telomere protection from DNA repair pathways.33 This evidence concerns the gene TERF2 and telomere syndrome.