Curcumin gavage attenuates 5/6 nephrectomy-induced systemic and glomerular hypertension, hyperfiltration, glomerular sclerosis, and interstitial fibrosis, which is associated with increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) (Tapia et al., 2012). Here, NFE2L2 is linked to Glomerular sclerosis.