AGT and hypertensive disorder: In addition, these authors further demonstrate that curcumin treatment reduces Ang II-induced hypertension and vasoconstriction, concomitant with reduction of AT1R expression in the arteries, indicating that downregulation of AT1R is an important mechanism for curcumin to prevent the development of hypertension in an Ang II-induced hypertensive models (Yao et al., 2016).