MMP9 and Hypertension: A study by Greenwald’s group showed that exposure of cadmium chloride results in hypertension, hypertrophic aortic wall, blunted vasodilation, increased aortic stiffness, collagen deposition, and accumulation of MMP-2 and MMP-9 levels in the aortic medial wall of male ICR mice, effects are largely ameliorated by tetrahydrocurcumin, a major metabolite of curcumin (Sangartit et al., 2014).