Chemerin, a novel adipokine, plays a crucial role in the process of atherosclerosis by acting on chemokine-like receptor 1 (CMKLR1) (Liu et al., 2019), and the chemerin/CMKLR1 signaling pathway is also involved in the regulation of intimal hyperplasia and hypertension (Kennedy et al., 2016; Artiach et al., 2018). Here, RARRES2 is linked to hypertensive disorder.