EDN1 and hypertensive disorder: ET-1, a vasoactive peptide of 21-amino acids, is known as one of the most potential vasoconstrictors, which plays a critical role in the development of hypertension by acting on endothelin receptor type A (ETAR), type B1 (ETB1R), and type B2 (ETB2R) coupled with G proteins (Sakurai et al., 1990; Kedzierski et al., 2003).