PTGS2 and hypertensive disorder: Accordingly, (Li and Tian, 2016) examined this hypothesis and found that demethoxycurcumin, a major component of Curcuma longa L, elevated endothelium-dependent contractions in renal arteries of SHR by normalization of COX-2 expression, indicating the benefits of demethoxycurcumin in endothelium-dependent contractions during the development of hypertension (Li and Tian, 2016).