TAP1 and neoplasm: Although there is a discrepancy in expression of MHC class I between high stemness versus low stemness malignant cells from these two cohorts, there is significant lower expression of MHC class II molecules and TAP1 in high stemness malignant cell population (Figure 3 and Supplemental Figure S3-S4), which indicates that the MHC II pathway in iCCA CSCs likely contributes to immune evasion during tumor initiation and progression.