In addition, larger tumor size (>5 cm: HR 1.16, 95% CI 1.10–1.22, p < 0.01), N2 stage (HR 1.22, 95% CI 1.14–1.32, p < 0.01), elevated CEA (HR 1.51, 95% CI 1.41–1.62, p < 0.01), and poorly differentiated grade (HR 1.85, 95% CI 1.57–2.18, p < 0.01) were also significantly associated with an increased ACM (Table 4). Here, CEACAM5 is linked to neoplasm.