In addition, we found that COX-2 overexpression was significantly associated with the tumor stage and T stage of laryngeal cancer (tumor stage, OR = 3.26, 95% CI: 2.13–4.98, P < 0.05; recurrence, OR = 10.71, 95% CI: 3.54–32.38, P < 0.05). This evidence concerns the gene PTGS2 and neoplasm.