In a genome-wide association study involving 993 laryngeal squamous cell carcinoma patients and 1,995 controls, researchers found the three most significant SNPs—rs174549, rs2857595, and rs10492336—which are located in FASD1, AIF1, and TBX5 genes, respectively (70). The gene discussed is TBX5; the disease is laryngeal squamous cell carcinoma.