Finally, we estimated the prognostic value of COX-2 overexpression in laryngeal cancer, and significant correlations between COX-2 overexpression and poor prognosis of laryngeal cancer were found both in Asians and Caucasians (total, HR = 1.73, 95% CI: 1.23–2.24; survival in Asians, HR = 2.59, 95% CI: 1.27–3.92, P < 0.05; survival in Caucasians, HR = 1.59, 95% CI: 1.03–2.14, P < 0.05) (Figure 2 and Table 3). The gene discussed is PTGS2; the disease is laryngeal carcinoma.