CAMKK2 and lung cancer: For instance, α-KG can bind to calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) and stimulate the activity of AMPK, a substrate of CAMKK2, thereby inhibiting the mTOR pathway, balancing redox status and ultimately reactivating anoikis resistance signaling in LKB1-deficient lung cancer (136).