The top 10 genes negatively correlated with LAMP2 expression were AGR3, CDC42EP5, CLRN3, SMIM24, PIGR, IHH, DMBT1, MIR3131, MS4A8, and TM4SF5. PIGR has been considered as a candidate prognostic biomarker in several cancers, and a previous study reported that reduced PIGR expression was associated with more aggressive tumors in the distal esophagus (50, 51). This evidence concerns the gene CLRN3 and cancer.