After METTL3 and ALKBH5 knockdown, E-cadherin protein level was significantly increased, and Nanog, Oct4, and Sox2 were decreased significantly (Figure 5A), indicating that knockdown of METLL3 or ALKBH5 potentially regulates stemness of NSCLC CSCs. The gene discussed is SOX2; the disease is non-small cell lung carcinoma.