XPC and Familial prostate cancer: For instance, in a micro-RNA (miR) screen of prostate cancer, miR-890, which directly inhibited transcription of XPC along with other DNA repair proteins, led to increased sensitivity to ionizing radiation, although further mechanistic testing indicated that IR-sensitization by miR-890 persisted in XPC knock-down cells, suggesting an indirect role of XPC in double-strand break repair and overlapping gene-functionality in IR-sensitization (152).