Females carrying XPC 939Gln/Gln vs. XPC 939Lys/Gln. 939Gln/Gln had significantly increased risk of lung cancer as well as other females and males with several combination of polymorphisms in XPC, XPD (Lys751Gln), hOGG1 (Ser326Cys) and XRCC1 (Arg399Gln). The gene discussed is ERCC2; the disease is lung carcinoma.