Along with SNPs in two other NER proteins, XRCC1 and XRCC2, the XPC Ala499Val polymorphism was found to correlate to a decreased odds of ovarian cancer (OR 0.35) while the XPC Lys939Gln polymorphism was associated with an increased risk of ovarian cancer (OR 1.72) in a dominant genetic model (93). The gene discussed is XRCC1; the disease is ovarian cancer.