(35) found that circPACRGL was significantly upregulated in colorectal cancer cells (CRC) after tumor-derived exosomes addition and indicated that cancer-derived exosomal circPACRGL played an oncogenic role in CRC proliferation and metastasis. In gastric cancer tissues and serum, the expression of exosomal circSHKBP1 was significantly increased and related to advanced TNM stages and poor prognosis, while exosomal circSHKBP1 regulated the miR-582-3p/HUR/VEGF pathway, suppressed HSP90 degradation, and promoted GC cell proliferation, migration, invasion, and angiogenesis (36). This evidence concerns the gene VEGFA and colorectal carcinoma.