CircWHSC1 played a tumor-promoting role in HCC by elevating HOXA1 through sponging miR-142-3p, and circTMEM45A acted as a miR65 sponge to relieve the repressive effect of miR-665 on its target insulin growth factor 2(IGF2), upregulation of IGF2 and HCC progression (45, 48). The gene discussed is IGF2; the disease is hepatocellular carcinoma.