Hsa_circ_0004658 secreted by RBPJ overexpressed macrophages can inhibit proliferation and induce apoptosis in HCC cells by sponging miR-499b-5p and downregulating JAM3 expression (53). Circ_0061395 was upregulated in serum exosomes of HCC patients. Circ_0061395 inhibition reduced malignant behavior of HCC cells, induced cell cycle arrest, apoptosis, repressed proliferation, invasion, and migration of HCC cells, by regulating the miR-877-5p/PIK3R3 axis (47). Here, JAM3 is linked to hepatocellular carcinoma.