(41) reported that exosomal circUHRF1 was predominantly secreted by HCC cells, circUHRF1 inhibited NK cell function by upregulating the expression of TIM-3 via degradation of miR-449c-5p, thereby promoting immune evasion and resistance to anti-PD1 immunotherapy in HCC. Here, HAVCR2 is linked to hepatocellular carcinoma.