CAR-T cells that target BCSC markers, in particular Human Epidermal Growth Factor Receptor (HER)2, GD2 and CD44v6 (NCT04430595), CD44v6 (NCT04427449), Epithelial Cell Adhesion Molecule (EpCam, NCT02915445) and CD133 (NCT02541370), are currently undergoing clinical studies involving BC patients. The gene discussed is ERBB2; the disease is breast cancer.