IL6 and neoplasm: Besides mAb, small molecules have also been used to target the CSC/immune-microenvironment interaction and have reached the clinic; for example, ruxolitinib inhibits the IL-6/JAK/STAT pathway (NCT02066532, NCT02041429, NCT02876302, NCT02120417, NCT01562873, NCT01594216, NCT03012230) with evidence of clinical activity (24), while reparixin targets the IL-8 receptor CXCR1, selectively depletes CSCs in vitro and reduces tumor growth and metastasization in vivo (81).