HNF4A and colorectal adenocarcinoma: Furthermore, TELO2 knockdown with siRNAs resulted in the inhibition of Wnt-induced β-catenin/TCF-dependent transcriptional activation (Figure 3A) and reduction of the β-catenin level in HEK293 (Figures 3B and 3C) and human colorectal adenocarcinoma (HT-29; Figure 3D) cells.