KLK3 and cancer: A subset of these patients can be further stratified into very-low risk disease, which the National Comprehensive Cancer Network defines as having clinical stage T1c, grade group 1, PSA less than 10 ng/mL, fewer than 3 prostate biopsy fragments/cores positive, less than 50% cancer in each fragment/core, and PSA density less than 0.15 ng/mL/kg [4].