IL2 and Alzheimer disease: Although its role in the context of AD is not clear, decreased levels of IL-2 in the hippocampus have been associated with exacerbated AD pathology in mice (Alves et al., 2017), and treatment of AD mice with exogenous IL-2 significantly reduced AD pathology via increased regulatory T cell activity (Dansokho et al., 2016; Alves et al., 2017).