In AD, the IL-1 family has been of interest due to its close association with neuroinflammation (Shaftel et al., 2008; Italiani et al., 2018; Liu and Quan, 2018), the presence of genetic mutations in IL-1 that link to AD (Licastro et al., 2004; Rainero et al., 2004), and the presence of IL-1 cytokines in AD brains (Swanson et al., 2018). Here, IL1B is linked to Alzheimer disease.