Some of the changes in epigenetic regulation of glutamate transporter expression may also be involved in depression-like behaviors and cognitive alterations secondary to neurological conditions, such as subarachnoid hemorrhage, in which astrocyte histone deacetylase 2 negatively regulates the expression of GLT-1 (Tao et al., 2020). This evidence concerns the gene SLC1A2 and major depressive disorder.