Salidroside (Salid), which is the main active ingredient of Rhodiola rosea, is commonly used for relieving high altitude sickness and replenishing vital energy.13 However, increasing number of studies have demonstrated that Salid can be an efficient anticancer drug due to its ability to inhibit the growth of bladder tumors through the activation of ERS.14 An investigation of the crosstalk between Salid and ERS manifested that Salid induced cancer cell apoptosis and restrained progress mainly by regulating the signaling pathways of AMPK/mTOR.15 This evidence concerns the gene MTOR and cancer.