HAVCR1 and acute kidney injury: In contrast, with regard to the effect of sympathetic denervation by SCGx on the progression of IR-induced AKI injury, our study showed aggravated renal morphological and functional changes in denervated rats with renal IR injury, manifested by the elevated biochemical markers such as BUN, KIM-1 and NGAL, as well as severe histopathological alteration.