- Middle-Aged and older people (95) - Subjects aged 50–74 years (96) - Subjects aged 55 years and over (97) - Very old people (age 90–108 years old) (98) - Females with MCI, apoE4 carriers (99) - Healthy middle-aged man population (100) - Oldest-Old aged 80 years and older (101) - Older adults aged 65 and over (102) - Patients with PD (103, 104) - Patients with ALS (105–107) - Patients with HD (108) - Patients with AD (109). This evidence concerns the gene APOE and Huntington disease.