CCR2 and Hepatic fibrosis: Through the study, when the CCR2 gene was knocked down in mice, Ly6Chi was reduced and Ly6Clo quantity was increased in the liver, corresponding to the reduction of HSC activation and some relief of liver fibrosis, indicating that Ly6Chi has proinflammatory and profibrotic properties, while Ly6Clo has anti-inflammatory and antifibrotic properties.