Autophagy of LSEC also enables chemokines, inflammatory factors such as C-C chemokine ligand 2 (CCL2), C-C chemokine ligand 2 (CCL5), and interleukin-6 (IL-6) are enhanced, promoting the hepatic inflammatory response and thus liver fibrosis [34]. This evidence concerns the gene CCL2 and Hepatic fibrosis.