AKT1 and Hepatic fibrosis: Studies have shown [141, 142] that the protective effect of Yinchenhao decoction on liver fibrosis is closely related to PI3K-Akt, TNF, and MAPK signaling pathways and the components of the decoction such as aloe vera emodin, rheinic acid, kaempferol, and quercetin are important components for liver protection, and they not only have therapeutic effects on liver injury caused by CCL4 but also improve fatty liver and inhibit cirrhosis, as well as improving liver fibrosis by inhibiting HSC proliferation and activation.