TGFB1 and Hepatic fibrosis: Activated KC generates various types of mediators of liver fibrosis progression (e.g., TGF-β, PDGF, IL-1β, MMPs, CCL2, cysteine-3, etc.)and also accelerates the progression of liver fibrosis by activating HSC to produce large amounts of collagen, allowing ECM to settle and aggregate [26].