TIMP1 and Hepatic fibrosis: Fibrosis is characterized by the production of myofibroblasts (MFB) that promote scar formation by activated Hepatic stellate cells (HSC), and the synthesis of extracellular matrix (ECM) by both MFB and HSC, and the balance of ECM is regulated by both matrix metalloproteinases (MMP) and tissue inhibitor of metalloproteinases (TIMP) that ultimately target HSC to form fibrosis, so it can be said that the dynamics of ECM regulation process is the process of liver fibrosis formation.