TP53 and metabolic dysfunction-associated steatotic liver disease: Emodin extracted from various anthraquinones further affects the fibrotic process by inhibiting epithelial-mesenchymal transition (EMT), reducing Ly6Chi macrophage infiltration Ly6Chi [128], mediating the p53 signaling pathway to induce HSC apoptosis and the TLR4 pathway to slow down inflammation production and lipid deposition in NAFLD models [129, 130].