STAT1 and skin disorder: In addition, GZFL extract significantly reduced levels of chemokine (macrophages are derived from chemokines (MDC), regulated upon activation of normal T cell expressed sequence (RANTES)), and production of IL-8 and IL-8 mRNA in TNF-α/interferon-gamma- (IFN-γ-) stimulated HaCaT human keratinocytes by blocking the signal transducer and activator of transcription 1 (STAT1) pathway, which contributed to the anti-inflammatory effect of GZFL on skin disorders [94].