ICAM1 and atherosclerosis: One study reported that GZFL improved atherosclerosis by downregulating the levels of triglyceride (TG), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and ICAM-1 (a marker of activation of the endothelial cell) in the serum, as well ICAM-1 expression in the aorta, of rats fed a high-cholesterol diet [83].