BDNF and obesity due to melanocortin 4 receptor deficiency: Albiflorin has antidepressant-like effects by increasing hippocampal expression of 5-hydroxytryptamine (5-HT)/norepinephrine (NE) and brain-derived neurotrophic factor (BDNF) [22] and also ameliorates obesity by modulating the expression of thermogenic genes [23].