PTEN and ovarian cancer: What's more, serum derived from rats administrated with GZFL extract in cisplatin-resistant human ovarian cancer SKOV3/DDP cells was a promising way to overcome cisplatin-resistant by inhibiting the expression of metadherin (MTDH), inducing the expression of phosphatase and tensin homolog (PTEN), and improving the interaction between MTDH and PTEN [65].