The results of this study showed that Gandakang tablets plus methylprednisolone were associated with higher efficacy and lower levels of IgG, IgM, IgA, TNF-α, IL-4, and IL-6 versus methylprednisolone, indicating that the combined treatment can effectively reduce the level of inflammatory factors in SLE patients, regulate their immune function, and facilitate rapid recovery. Here, TNF is linked to systemic lupus erythematosus.