BRAF and cancer: This is notable, as KRAS is often stated to be the most commonly mutated proto-oncogene.6 Our study found KRAS mutated in 11% of all cancers as opposed to the 30% mutation rate often quoted, including in the recent literature.7,8 We also report that a major effector of Ras proteins, encoded by the gene BRAF has a mutation incidence of 8%, almost as common pan-cancer as KRAS.