Given that IL-21 has an indirect antitumor activity by enhancing the cytotoxic activity and proliferation of CD8 T cells and NK cells and that it can promote apoptosis of the B-cell at certain stages by upregulation of pro-apoptotic proteins such as Bim and downregulation of anti-apoptotic proteins, there has been an interest in studying IL-21 in the treatment of lymphoma. Here, IL21 is linked to lymphoma.