HAVCR2 and HIV infectious disease: Higher TIM-3 expression in NK cells has been considered a marker of better prognosis during HIV infection since its down regulation is indicative of IFN-γ deficient response (44) and interestingly, strong and direct correlations were also found between miRNA-155-5p levels, miRNA upregulated on EARLY treated HIV-1 young adults, and MFI expression of TIM-3 in CD56high NK cells.