In addition to everything described so far related to miRNA-155-5p, that miRNA and miRNA-1248, which is associated with good survival prognoses in cancer (38), both upregulated on EARLY treated HIV-1 patients, strongly correlated with the activation marker HLA-DR, the natural cytotoxicity family activation receptor NKp30 and the inhibiting receptor NKG2A expressed on NK cells and more specifically on the main cytotoxic NK subset, CD16high and the activated and mature CD56negCD16+ NK cells, described as a subset with impaired effector functions in HIV-1 infection (39). The gene discussed is NCR3; the disease is cancer.