The lncRNA RP11-424C20.2 regulates the expression of the UHRF1 gene (ubiquitin-like containing PHD ring finger 1) by sponging miR-378a-3p; the RP11-424C20.2/UHRF1 axis is strongly associated with a better outcome in thymoma patients, which is related to the different types of infiltrating immune cells, such as B cells, macrophages, CD8+ and CD4+ cells, neutrophils, and dendritic cells. The gene discussed is UHRF1; the disease is thymoma.