The levels of S1-specific antibodies in vaccinees did not correlate with CD4+ or CD8+ T cell responses, whereas in COVID-19 patients anti-S1 IgG antibody levels had a trend with CD4+ (r=0.487, p=0.0667) and CD8+ (r=0.386, p=0.1551) T-cell responses. The gene discussed is CD8A; the disease is COVID-19.