However, in view of the multiple cytokines affecting the NK cells in the CS context and the elevation of IL-15 (NK stimulator), the effect of IL-6 is surpassed, with a net result of increased granzyme B. Our model shows the high accuracy of liver injury prediction in severe COVID-19, by combining IL-6 and granzyme B as predictors. The gene discussed is GZMB; the disease is COVID-19.