With respect to Mycobacterium bovis disease, as a serious complication of Bacillus Calmette-Guérin (BCG) vaccination, ranging from local disease (known as BCGitis) to disseminated disease (BCGosis), occurred in twelve cases with CID, nine cases with inborn defects of the IL-12/IFN-γ axis, three cases with syCID, and one case with phagocytic disorder. Here, IFNG is linked to combined immunodeficiency.