Although selection criteria for LT in HCC patients are becoming more and more sophisticated, all established parameters are still “imperfect.” In any group with a negative prognosis determined by the available criteria, there remains a small proportion of patients who will achieve long-term survival “against all odds.” This has been shown for G3 tumors, PET-positive tumors, an AFP >1,000 ng/ml, and even for patients with macrovascular invasion (65). Here, AFP is linked to hepatocellular carcinoma.