Elevated plasma levels of OPG are associated with coronary artery atherosclerosis (Rhee et al., 2005), carotid artery stenosis (Kadoglou et al., 2008), and peripheral artery atherosclerosis (Chen et al., 2017; Helske et al., 2007). The gene discussed is TNFRSF11B; the disease is coronary atherosclerosis.