CNR1 and experimental autoimmune encephalomyelitis: Preclinical studies utilizing experimental autoimmune encephalomyelitis MS models have observed reduced expression of CB1R among the striatum and cortex of rats (Berrendero et al., 2001), and mice deficient in CB1R used in experimental autoimmune encephalomyelitis MS models exhibit enhanced neurodegeneration compared to control subjects (Pryce et al., 2003).