CNR1 and Anxiety: Brain regions relevant in feelings of anxiety and fear include the prefrontal cortex, hippocampus, amygdala, hypothalamic nuclei, and the bed nucleus of the stria terminalis (Lafenetre et al., 2007), regions with notable expression of neuronal CB1R. Additionally, CB2R present within the periphery and the CNS, have been implicated in both anxiety disorders and anxiety regulation (Garcia-Gutierrez and Manzanares, 2011; Liu et al., 2017; Patel et al., 2017).