Preclinical research utilizing a genetic mouse model of ALS presents conflicting observations regarding CB1R. Compared to healthy controls, reductions in spinal cord motor neuron CB1R expression has been observed in the early, pre-symptomatic stage in a mouse ALS model, with an elevation of expression observed in the symptomatic stage (Zhao et al., 2008). Here, CNR1 is linked to amyotrophic lateral sclerosis.