As partial agonists buspirone and tandospirone both improved AD patient mood and behavior, further research into 5-HT1A modulation, via CBD or other cannabinoids with serotonergic activity, may provide promising therapeutics able to alleviate AD associated cognitive dysfunction, behavioral decline and memory impairment (Salzman, 2001; Sato et al., 2007). The gene discussed is HTR1A; the disease is Alzheimer disease.