MAPT and Alzheimer disease: Alzheimer’s disease (AD) is the most common neurodegenerative disease that contributes to approximately 60–80% of all dementia cases globally (Erkkinen et al., 2018) and is characterized by the formation of β-amyloid plaques, phosphorylated tau proteins, formation of neurofibrillary tangles, glial activation, and neuronal death (Scheltens et al., 2021).