Figure 1shows the spatial distribution of CB1R, CB2R, and 5-HT1A receptors within the brain. Agonism of 5-HT1A receptors has been shown to inhibit nociception (Gjerstad et al., 1996; Bardin et al., 2003; Haleem & Nawaz, 2017), exhibit neuroprotective effects (Miyazaki et al., 2013; Isooka et al., 2020; Kikuoka et al., 2020), and alleviate the severity of several anxiety disorders (Sussman and Joffe, 1998; Campos and Guimarães, 2008). Here, CNR1 is linked to anxiety disorder.