Like CB1R, 5-HT1A receptors are present in high densities throughout the CNS in areas associated with emotional control and anxiety, including regions such as the hippocampus, amygdala, and cerebral cortex (Mestikawy et al., 1991; Wang et al., 2009; Marcinkiewcz et al., 2016). Here, CNR1 is linked to Anxiety.