As the most common cause of neurodegenerative dementia and one of the top medical concerns worldwide, AD is characterized by extracellular amyloid-β (Aβ) plaques, intracellular tau aggregation into neurofibrillary tangles (NFTs), neuronal synaptic dysfunction, and neuronal loss (Hinz and Geschwind, 2017). This evidence concerns the gene MAPT and Alzheimer disease.