In the K/BxN serum-induced model of RA (Christianson et al., 2012), NR4A1-3 mRNA levels were elevated in inflamed ankles and NR4A2 expression was potently suppressed by dexamethasone and intra-articular injections of salmon calcitonin and hyaluronic acid (Ryan et al., 2013). This evidence concerns the gene CALCA and rheumatoid arthritis.