However, NR4A2 was categorized as a downregulated gene in these OA synovial datasets, in contrast to its upregulation in OA cartilage (Mix et al., 2007), RA synovium (Murphy et al., 2001; McEvoy et al., 2002; Ralph et al., 2005; Aherne et al., 2009; Ralph et al., 2010), and hTNF-α joints in this study. This evidence concerns the gene NR4A2 and rheumatoid arthritis.