The adjusted GAPSS (aGAPSS), a simplified version of GAPSS, in which the less available anti- phosphatidylserine/prothrombin (aPS/PT) measurement was excluded, was validated in recent years for assessment of thrombotic recurrence in the general population of APS (Radin et al., 2017; Radin et al., 2019). This evidence concerns the gene F2 and autoimmune polyendocrinopathy.