IL6 and Insulin resistance: First, anti-inflammatory naringin can effectively diminish the secretion of diabetes-associated inflammatory molecules, such as interleukin-6 (IL-6) and TNF-α, both of which contribute to insulin resistance and hyperglycemia (Hotamisligil et al., 1993; Dandona et al., 2004; Krogh-Madsen et al., 2006; Alam et al., 2014; Chen et al., 2016).