First, the values of TP, VLF, LF, and HF were all significantly decreased in the DM group compared with those in the control group (p < 0.01), and the abnormalities were mitigated in the DM + P2Y14 shRNA group as well as the DM + naringin group (p < 0.01). The gene discussed is P2RY14; the disease is hydrops fetalis.