Interference of IGF-1 receptor tyrosine kinase and NAD(P)H oxidase mitigated IGF-1 induced HDAC5 phosphorylation, thereby suggesting that HDAC5 phosphorylation is related to NAD(P)H oxidase-induced ROS generation and vascular disorders (Zhao et al., 2020). The gene discussed is HDAC5; the disease is vascular disorder.