According to this hypothesis, SCN1A haploinsufficiency that results in a defective encoded protein channel NAV1.1 affects various parts of the brain, including the cortex, cerebellum, basal ganglia, and hypothalamus, causing clinical signs, such as epileptic seizures, ataxia, neuronal dysregulation, and sleep disorders (56). The gene discussed is SCN1A; the disease is Ataxia.